The most common and most likely answer to this crossword clue is the 7 letter word SIGNORA
S
I
G
N
O
R
A
More clues leading to the result SIGNORA
- Lady’s indication — test 75% complete
- Son nearly cut a lady from Italy
- Topless dress is to be sent back to Italy, madam
- Duck inside, a ring’s produced and she’s married
- Venetian lady soaring all over the place
- Organist endlessly amazed lady in Milan
- Leo, for example, or a lady abroad
- Evidence links nothing to artist at Italian address
- Trace soldiers with a wife abroad
- Novel soaring, Italian title
Buddy explains!

The straight part
We know that "Lady" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lady = signora.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SIGNORA mean?
SIGNORA noun- Mrs; madam; title of address or respect for women in Italy.