Cryptic crossword clue
Lady’s skin condition: one after opening has look inside 8

The most common and most likely answer to this crossword clue is the 8 letter word CHLOASMA

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Buddy explains!

The straight part
We know that "Lady’s skin condition" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lady’s skin condition = chloasma.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CHLOASMA mean?

CHLOASMA noun
  1. Melasma; a cutaneous condition with yellow or yellowish-brown pigmented spots

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