The most common and most likely answer to this crossword clue is the 6 letter word GRAPPA
G
R
A
P
P
A
More clues leading to the result GRAPPA
- Doctor entertains artist with piano and a brandy
- Drink that's right during interval? Pop
- Spirit of good old man accepting modern style of music
- Strong liquor: relative's also knocked out by a pint, initially?
- Good old man embracing modern music? That's the spirit!
- Blame accepted by doctor given a drink
- ‘King George’, a soft old man’s tipple
- Greek father is up and down for a drink
- Good old man accepts criticism for Italian spirit
- Doctor accepts rebuke when getting a drink
Buddy explains!

The straight part
We know that "Spirit" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spirit = grappa.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GRAPPA mean?
GRAPPA noun- An Italian grape-based spirit of between 80 and 100 proof, made from the distillation of pomace.
- A variety or serving of grappa.