The most common and most likely answer to this crossword clue is the 8 letter word CRIPPLED
I've seen this crossword clue in The Daily Telegraph
C
R
I
P
P
L
E
D
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
Crossword Answer definitions
CRIPPLED verb- To make someone a cripple; to cause someone to become physically impaired
- To damage seriously; to destroy
- To release a product (especially a computer program) with reduced functionality, in some cases, making the item essentially worthless.
- To nerf something which is overpowered
- (usually offensive) Having a less than fully functional limb, or injuries which prevent full mobility.
- (usually offensive) Having any difficulty or impediment which can be likened to a crippling injury.