The most common and most likely answer to this crossword clue is the 9 letter word HAMSTRING
I've seen this crossword clue in Independent
H
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More clues leading to the result HAMSTRING
- Cord bringing meat over some horses
- Poor actor on series is handicap
- . Runner might have trouble with this actor on series
- Lame man rights wrong
- Disable mast originally handling mobile phone
- Meat and fibre in hamper
- Treatment applied to man’s right leg tendon
- Frustrate man’s right to change
- Thread to go under amateur athlete’s vulnerable tendon
- Thread supporting actor pulled? It might be
Buddy explains!

The straight part
We know that "(make) lame" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case (make) lame = hamstring.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HAMSTRING mean?
HAMSTRING noun- One of the great tendons situated in each side of the ham, or space back of the knee, and connected with the muscles of the back of the thigh.
- The biceps femoris, semimembranosus, and semitendinosus muscles.
- To lame or disable by cutting the tendons of the ham or knee; to hough.
- To cripple; to incapacitate; to disable.