The most common and most likely answer to this crossword clue is the 10 letter word UNLETTERED
I've seen this crossword clue in Independent
U
N
L
E
T
T
E
R
E
D
More clues leading to the result UNLETTERED
Buddy explains!
The straight part
We know that "not familiar with classical works?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case not familiar with classical works? = unlettered.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNLETTERED mean?
UNLETTERED adjective- Not instructed in letters; not well educated; unable to read
- Not expressed in or marked with letters