The most common and most likely answer to this crossword clue is the 6 letter word EMPIRE
E
M
P
I
R
E
More clues leading to the result EMPIRE
- Group of countries anger MEP, disturbed initially
- European power in tricky situation, trying to hold this?
- Domain of politician in Ireland
- English politician with passion for supreme dominion
- European country keeping parliamentarian in government
- English member’s anger: Britain’s lost it!
- European politician’s anger with group of states …
- Great power of representative in republic
- Anger after Eastern politician’s found in powerful organisation
- English judge lacking proper authority
Buddy explains!

The straight part
We know that "Large business" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case large business = empire.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EMPIRE mean?
EMPIRE adjective- (furniture) Following or imitating a style popular during the First French Empire (1804–1814).
- (of wine) Produced in a dependency of the British Empire or Commonwealth of Nations.
- A political unit, typically having an extensive territory or comprising a number of territories or nations (especially one comprising one or more kingdoms) and ruled by a single supreme authority.
- A political unit ruled by an emperor or empress.
- A group of states or other territories that owe allegiance to a foreign power.
- An expansive and powerful enterprise under the control of one person or group.
- (Absolute) control, dominion, sway.