Cryptic crossword clue
Large duke suddenly starts confining guards 7

The most common and most likely answer to this crossword clue is the 7 letter word SHIELDS

I've seen this crossword clue in The Guardian
S
H
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Buddy explains!

The straight part
We know that "guards" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guards = shields.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SHIELDS mean?

SHIELDS noun
  1. Anything that protects or defends; defense; shelter; protection.
  2. A shape like that of a shield; usually, an inverted triangle with sides that curve inward to form a pointed bottom, commonly used for police identifications and company logos.
  3. A large expanse of exposed stable Precambrian rock.
  4. A place with a toilet seat: an outhouse; a lavatory.
  5. Parts at the front and back of a vehicle which are meant to absorb the impact of a collision
SHIELDS verb
  1. To protect, to defend.
  2. To protect from the influence of

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