The most common and most likely answer to this crossword clue is the 4 letter word PEPO
P
E
P
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Buddy explains!
The straight part
We know that "Large fruit" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case large fruit = pepo.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PEPO mean?
PEPO noun- A fruit of plants of the gourd family Cucurbitaceae, possessing a hard rind and producing many seeds in a single, central, pulpy chamber.
- A plant producing such a fruit.