The most common and most likely answer to this crossword clue is the 6 letter word HORNET
I've seen this crossword clue in The Times
H
O
R
N
E
T
More clues leading to the result HORNET
- New throne for queen, perhaps
- Large insect runs inside on the ground
- Insect moving north-east
- Old comic‘s tip on film
- After instrument goes from cold to hot, it buzzes
- Insect: swarm died out around November time
- Small flier then, or cuckoo
- Ranger regularly bitten by tropical insect
- One stinging nettle finally confused with thorn
- Hard men trap insect
Buddy explains!

The straight part
We know that "Large insect" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case large insect = hornet.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HORNET mean?
HORNET noun- A large wasp, of the genus Vespa, having a brown-and-yellow-striped body and the ability to inflict a serious sting.
- A person who pesters with petty but ceaseless attacks.