Cryptic crossword clue
Large insect runs inside on the ground 6

The most common and most likely answer to this crossword clue is the 6 letter word HORNET

I've seen this crossword clue in The Times
H
O
R
N
E
T


Buddy explains!

The straight part
We know that "Large insect" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case large insect = hornet.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HORNET mean?

HORNET noun
  1. A large wasp, of the genus Vespa, having a brown-and-yellow-striped body and the ability to inflict a serious sting.
  2. A person who pesters with petty but ceaseless attacks.

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