The most common and most likely answer to this crossword clue is the 7 letter word BASSOON
I've seen this crossword clue in The Daily Telegraph
B
A
S
S
O
O
N
More clues leading to the result BASSOON
- Instrument produced by graduates thus performing
- Instrument supplied by graduates before long
- Fool in favour of 2’s grandfather
- Donkey in favour? Blow that!
- Fool in favour of woodwind instrument
- It is played to keep fool in favour
- Large instrument could be graduate’s in a short while
- Graduates quickly finding instrument
- Instrument that may be graduate's shortly
- Instrument playing encapsulating old instrument
Buddy explains!

The straight part
We know that "Large instrument" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case large instrument = bassoon.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BASSOON mean?
BASSOON noun- A musical instrument in the woodwind family, having a double reed and playing in the tenor and bass ranges.
- To play the bassoon.
- To make a bassoon-like sound.