The most common and most likely answer to this crossword clue is the 4 letter word MEOW
I've seen this crossword clue in The Guardian
M
E
O
W
More clues leading to the result MEOW
- Beastly sound from male with rising grief
- Mike’s misery over Abyssinian’s remark?
- Seagull circles round, making beastly noise
- Homeowner stifles beastly outburst
- Large number coming to grief over catty remark
- Mike’s misery over Persian’s remark?
- Beastly cry from yours truly: ‘That hurt!’
- Tom’s cry for loose women to remove Nick’s top
- Crying sound from setter’s response to pain
- Catcall from writer that hurt!
Buddy explains!

The straight part
We know that "catty remark/catty remark" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case catty remark/catty remark = meow.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MEOW mean?
MEOW noun- The cry of a cat.
- The drug mephedrone.
- Of a cat, to make its cry.
- The cry of a cat.
- Said in reply to a spiteful or catty comment.
- Said to denote seductiveness, mimicking a growl.