Cryptic crossword clue
Large number coming to grief over catty remark 4

The most common and most likely answer to this crossword clue is the 4 letter word MEOW

I've seen this crossword clue in The Guardian
M
E
O
W


Buddy explains!

The straight part
We know that "catty remark/catty remark" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case catty remark/catty remark = meow.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MEOW mean?

MEOW noun
  1. The cry of a cat.
  2. The drug mephedrone.
MEOW verb
  1. Of a cat, to make its cry.
MEOW interjection
  1. The cry of a cat.
  2. Said in reply to a spiteful or catty comment.
  3. Said to denote seductiveness, mimicking a growl.

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