The most common and most likely answer to this crossword clue is the 6 letter word MYRIAD
I've seen this crossword clue in The Times
M
Y
R
I
A
D
More clues leading to the result MYRIAD
- Lots of farmworkers lacking aids when lifting
- Countless millions taken by milk producer rejected
- Large number in the Moroccan property I own
- A lot of McDonald’s milk products on the turn
- Innumerable milk suppliers having no space, becoming upset
- Many, many hollow air screws
- Army headmaster has diary problem
- Many miss working on farm, lacking support in retirement
- Countless insides of pyramids are in ruins
- The compiler’s free to hide answer for multitude
Buddy explains!

The straight part
We know that "Large number" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case large number = myriad.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MYRIAD mean?
MYRIAD noun- Ten thousand; 10,000
- A countless number or multitude (of specified things)
- (modifying a singular noun) Multifaceted, having innumerable elements
- (modifying a plural noun) Great in number; innumerable, multitudinous