The most common and most likely answer to this crossword clue is the 5 plus 2 plus 2 plus 6 letter word POINT OF NO RETURN
I've seen this crossword clue in The Guardian
P
O
I
N
T
O
F
N
O
R
E
T
U
R
N
More clues leading to the result POINT OF NO RETURN
- How tennis ace could be described in decisive moment
- Crucial moment for ace?
- Last chance for ace?
- Crunch not for pine nut, or nuts
- Pivotal moment, ace in tennis?
- Moment of truth is ace!
- Decisive stage when investments become unprofitable?
- Line beyond which investments yield nothing?
- Where advance is inevitable on Fot Niop?
- Discovered one footprint beside container in decisive moment
Buddy explains!
The straight part
We know that "Last chance" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case last chance = point of no return.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.