The most common and most likely answer to this crossword clue is the 8 letter word ULCERATE
U
L
C
E
R
A
T
E
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ULCERATE mean?
ULCERATE verb- To cause an ulcer to develop.
- To become ulcerous.
- (of a pollen grain) Having an ulcus, a rounded pore-like aperture, at one or both poles.