Cryptic crossword clue
Leaders of the group in defeat in low spirits? 6

The most common and most likely answer to this crossword clue is the 6 letter word ROTGUT

R
O
T
G
U
T

Buddy explains!

The straight part
We know that "low spirits?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case low spirits? = rotgut.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ROTGUT mean?

ROTGUT noun
  1. Raw or poor-quality alcoholic liquor

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