The most common and most likely answer to this crossword clue is the 9 letter word SINCEREST
S
I
N
C
E
R
E
S
T
More clues leading to the result SINCEREST
Buddy explains!
The straight part
We know that "Least affected" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case least affected = sincerest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SINCEREST mean?
SINCEREST adjective- Genuine; meaning what one says or does; heartfelt.
- Meant truly or earnestly.
- Clean; pure