The most common and most likely answer to this crossword clue is the 10 letter word RE-ELEVATE
I've seen this crossword clue in The Guardian
R
E
-
E
L
E
V
A
T
E
Buddy explains!
The straight part
We know that "pick up again" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pick up again = re-elevate.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.