Cryptic crossword clue
Leaving Earth on holiday? Take in Uranus at the beginning 10

The most common and most likely answer to this crossword clue is the 10 letter word EVACUATION

I've seen this crossword clue in The Guardian
E
V
A
C
U
A
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N

Buddy explains!

The straight part
We know that "Leaving/1" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case leaving/1 = evacuation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EVACUATION mean?

EVACUATION noun
  1. The act of evacuating; leaving a place in an orderly fashion, especially for safety.
  2. Withdrawal of troops or civils from a town, fortress, etc.
  3. The act of emptying, clearing of the contents, or discharging, including creating a vacuum.
  4. Voidance of any matter by the natural passages of the body or by an artificial opening; defecation; also, a diminution of the fluids of an animal body by cathartics, venesection, or other means.
  5. That which is evacuated or discharged; especially, a discharge by stool or other natural means.
  6. Abolition; nullification.

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