Cryptic crossword clue
Left here mindfully clutching instrument 8

The most common and most likely answer to this crossword clue is the 8 letter word THEREMIN

I've seen this crossword clue in The Daily Telegraph
T
H
E
R
E
M
I
N


Buddy explains!

The straight part
We know that "instrument" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instrument = theremin.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does THEREMIN mean?

THEREMIN noun
  1. An electronic musical instrument that generates sound of varying pitch and volume depending on the proximity of the musician’s hands to two antennae mounted on the instrument.

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