The most common and most likely answer to this crossword clue is the 8 letter word SOLITUDE
I've seen this crossword clue in The Daily Telegraph
S
O
L
I
T
U
D
E
More clues leading to the result SOLITUDE
- Privacy I lost, due to reform
- Concern, though not about one in isolation
- Note settled puddles regularly in deserted location
- Sidle out drunk to get freedom from company
- You can’t enjoy it in company
- Old suite refurbished for retirement
- Lout dies, confused in seclusion
- Left outside stewing in social isolation
- Hundred and one leaving concern in loneliness
- Trouble outside, left inside for privacy
Buddy explains!
The straight part
We know that "social isolation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case social isolation = solitude.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SOLITUDE mean?
SOLITUDE noun- Aloneness; state of being alone or solitary, by oneself.
- A lonely or deserted place.