The most common and most likely answer to this crossword clue is the 4 letter word EFTS
E
F
T
S
More clues leading to the result EFTS
- Amphibians once again focus on crossings
- English paper's showing creatures of land and water
- Amphibians, with short feet going in two directions
- Amphibians — not all left stranded
- Amphibians with feet going in two directions
- . Opponents a short distance apart, they’re amphibians
- Oddly effete, small crawlers
- Left snare to catch newts
- Newts somewhat bereft, sadly
Buddy explains!

The straight part
We know that "newts" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case newts = efts.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EFTS mean?
EFTS noun- A newt, especially the European smooth newt (Lissotriton vulgaris, syn. Triturus punctatus).