Cryptic crossword clue
Leg breaks keep a tight hold – tampering with nature? 7

The most common and most likely answer to this crossword clue is the 7 letter word CLONING

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Buddy explains!

The straight part
We know that "tampering with nature" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tampering with nature = cloning.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CLONING mean?

CLONING verb
  1. To create a clone of.
CLONING noun
  1. The production of an exact copy of an object.
  2. The production of a cloned embryo by transplanting the nucleus of a somatic cell into an ovum.

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