Cryptic crossword clue
Lessen stress with treatment for lack of sleep 12

The most common and most likely answer to this crossword clue is the 12 letter word RESTLESSNESS

I've seen this crossword clue in The Daily Telegraph
R
E
S
T
L
E
S
S
N
E
S
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RESTLESSNESS mean?

RESTLESSNESS noun
  1. The state or condition of being restless; an inability to be still, quiet, at peace or comfortable.

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