Cryptic crossword clue
Let Curie make handbag 8

The most common and most likely answer to this crossword clue is the 8 letter word RETICULE

R
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Buddy explains!

The straight part
We know that "handbag" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case handbag = reticule.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RETICULE mean?

RETICULE noun
  1. A reticle; a grid in the eyepiece of an instrument.
  2. A small women's bag made of a woven net-like material.

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