Cryptic crossword clue
Letter of alphabet representing measure of tyre inflation 3

The most common and most likely answer to this crossword clue is the 3 letter word PSI

I've seen this crossword clue in The Times
P
S
I


Buddy explains!

The straight part
We know that "Letter of alphabet/representing measure of tyre inflation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case letter of alphabet/representing measure of tyre inflation = psi.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PSI mean?

PSI noun
  1. The twenty-third letter of Classical and Modern Greek and the twenty-fifth letter of Old and Ancient Greek.
  2. A form of psychic energy.

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