Cryptic crossword clue
Letters from prisoners upsetting to nans 10

The most common and most likely answer to this crossword clue is the 10 letter word CONSONANTS

I've seen this crossword clue in The Daily Telegraph
C
O
N
S
O
N
A
N
T
S

Buddy explains!

The straight part
We know that "Letters" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case letters = consonants.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CONSONANTS mean?

CONSONANTS noun
  1. A sound that results from the passage of air through restrictions of the oral cavity; any sound that is not the dominant sound of a syllable, the dominant sound generally being a vowel.
  2. A letter representing the sound of a consonant.

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