The most common and most likely answer to this crossword clue is the 6 letter word GAMMAS
G
A
M
M
A
S
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The straight part
We know that "Letters" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case letters = gammas.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GAMMAS mean?
GAMMAS noun- The third letter of the Greek alphabet (Γ, γ), preceded by beta (Β, β) and followed by delta, (Δ, δ).
- The Gamma function, symbolized by Γ.
- A constant approximately equal to 0.55721566, symbolized by γ (also known as the Euler–Mascheroni constant).
- A non-SI unit of measure of magnetic flux density, equal to 1 nT.
- (industries) slope of log-log plot of video input and luminance output.
- A second-order measure of derivative price sensitivity, expressed as the rate of change in delta with respect to changes in the underlying asset price.
- A nonlinear operation used to encode and decode luminance or tristimulus values in video or still image systems.