The most common and most likely answer to this crossword clue is the 4 letter word UGLY
I've seen this crossword clue in The Guardian
U
G
L
Y
More clues leading to the result UGLY
- Unattractive leaders of union given little say, ultimately
- Limits to using lavatory? Nasty
- No oil painting of Burghley’s oddly extant: the opposite
- Unsightly inner core of Bruges gets left years
- Nasty bloke, putting head back, crossing line
- Unprepossessing, lumpy, extremely unpleasant
- Like certain sisters said ‘fruit’
- Regularly ignored fungal yeast’s beginning to be unsightly
- . Snug Lycra trousers lacking appealing features
- Heartlessly using lady is offensive
Buddy explains!

The straight part
We know that "Like certain sisters" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case like certain sisters = ugly.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UGLY mean?
UGLY noun- Ugliness.
- An ugly person or thing.
- A shade for the face, projecting from a bonnet.
- To make ugly (sometimes with up).
- Displeasing to the eye; not aesthetically pleasing.
- Displeasing to the ear or some other sense.
- Offensive to one's sensibilities or morality.
- Ill-natured; crossgrained; quarrelsome.
- Unpleasant; disagreeable; likely to cause trouble or loss.