Cryptic crossword clue
Like the cerebrum, initially large in the brainy, amazingly 12

The most common and most likely answer to this crossword clue is the 12 letter word LABYRINTHINE

I've seen this crossword clue in The Times
L
A
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Buddy explains!

The straight part
We know that "Like the cerebrum" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case like the cerebrum = labyrinthine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LABYRINTHINE mean?

LABYRINTHINE adjective
  1. Physically resembling a labyrinth; with the qualities of a maze.
  2. Convoluted, baffling, confusing, perplexing.

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