Cryptic crossword clue
Like to have sex? Setter’s looking to change gender first 10

The most common and most likely answer to this crossword clue is the 10 letter word TRANSITIVE

I've seen this crossword clue in Financial Times
T
R
A
N
S
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Buddy explains!

The straight part
We know that "Like to have" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case like to have = transitive.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRANSITIVE mean?

TRANSITIVE adjective
  1. Making a transit or passage.
  2. Affected by transference of signification.
  3. (grammar, of a verb) Taking a direct object or objects.
  4. (of a relation on a set) Having the property that if an element x is related to y and y is related to z, then x is necessarily related to z.
  5. (of a group action) Such that, for any two elements of the acted-upon set, some group element maps the first to the second.
  6. (of a graph) Such that, for any two vertices there exists an automorphism which maps one to the other.

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