Cryptic crossword clue
Likely to lead on 51 for 0 in Twenty20? 6

The most common and most likely answer to this crossword clue is the 6 letter word FLIRTY

I've seen this crossword clue in The Guardian
F
L
I
R
T
Y

Buddy explains!

The straight part
We know that "Likely to lead on" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case likely to lead on = flirty.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FLIRTY mean?

FLIRTY adjective
  1. Flirting, or seeming to flirt.

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