Cryptic crossword clue
Likely to respond and foolishly create about X’s opposite number 8

The most common and most likely answer to this crossword clue is the 8 letter word REACTIVE

I've seen this crossword clue in The Guardian
R
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A
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Buddy explains!

The straight part
We know that "Likely to respond" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case likely to respond = reactive.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REACTIVE mean?

REACTIVE adjective
  1. That reacts or responds to a stimulus
  2. That readily takes part in reactions
  3. Characterized by induction or capacitance rather than resistance.
  4. Reacting to the past rather than anticipating the future, not predictive.

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