Cryptic crossword clue
L'il Yankee found with spurious drug is blameless 4-5

The most common and most likely answer to this crossword clue is the 10 letter word LILY-WHITE

L
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L
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W
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Buddy explains!

The straight part
We know that "blameless" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case blameless = lily-white.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LILY-WHITE mean?

LILY-WHITE adjective
  1. A shade of the color white.
  2. Pure, unblemished, immaculate.
  3. Innocent, having a reputation beyond reproach.
  4. (sometimes derogatory) Caucasian; white.

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