Cryptic crossword clue
Line of approach when detailing evidence of sickness in mischief maker 9

The most common and most likely answer to this crossword clue is the 9 letter word ASYMPTOTE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Line of approach" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case line of approach = asymptote.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASYMPTOTE mean?

ASYMPTOTE noun
  1. A straight line which a curve approaches arbitrarily closely, as they go to infinity. The limit of the curve, its tangent "at infinity".
  2. (by extension) Anything which comes near to but never meets something else.
ASYMPTOTE verb
  1. To approach, but never quite touch, a straight line, as something goes to infinity.

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