The most common and most likely answer to this crossword clue is the 12 letter word CHEMISTRYSET
C
H
E
M
I
S
T
R
Y
S
E
T
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.