Cryptic crossword clue
Listening to internal murmurs, one American religious group shifted almost completely to Iona 12

The most common and most likely answer to this crossword clue is the 12 letter word AUSCULTATION

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does AUSCULTATION mean?

AUSCULTATION noun
  1. Diagnosis of disorders by listening to the sounds of the internal organs, usually using a stethoscope.

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