Cryptic crossword clue
Listlessness can make one reject help

The most common and most likely answer to this crossword clue is the 6 letter word ACEDIA

I've seen this crossword clue in The Guardian
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The straight part
We know that "Listlessness" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case listlessness = acedia.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACEDIA mean?

ACEDIA noun
  1. Spiritual or mental sloth.
  2. Apathy; a lack of care or interest; indifference.
  3. Boredom.

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