Cryptic crossword clue
Little calumnies can create reasonable doctrine 15

The most common and most likely answer to this crossword clue is the 15 letter word INTELLECTUALISM

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Buddy explains!

The straight part
We know that "reasonable doctrine" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case reasonable doctrine = intellectualism.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTELLECTUALISM mean?

INTELLECTUALISM noun
  1. The use or development of the intellect.
  2. The doctrine that knowledge is derived from pure reason.
  3. The use of mental attributes as a criterion or value (intellectual racism).

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