Cryptic crossword clue
Little devil in charge of one small building deprived of necessities? 12

The most common and most likely answer to this crossword clue is the 12 letter word IMPOVERISHED

I've seen this crossword clue in The Daily Telegraph
I
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Buddy explains!

The straight part
We know that "deprived of necessities" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case deprived of necessities = impoverished.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMPOVERISHED mean?

IMPOVERISHED verb
  1. To make poor.
  2. To weaken in quality; to deprive of some strength or richness.
  3. To become poor.
IMPOVERISHED adjective
  1. Reduced to poverty.
  2. Having lost a component, an ingredient, or a faculty or a feature; rendered poor in something; depleted.

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