The most common and most likely answer to this crossword clue is the 4 plus 6 letter word WEED KILLER
I've seen this crossword clue in The Times
W
E
E
D
K
I
L
L
E
R
Buddy explains!
The straight part
We know that "garden chemical" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case garden chemical = weed killer.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.