Cryptic crossword clue
Little priest has animal disease: … 8

The most common and most likely answer to this crossword clue is the 8 letter word SMALLPOX

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X

Buddy explains!

The straight part
We know that "disease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disease = smallpox.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SMALLPOX mean?

SMALLPOX noun
  1. An acute, highly infectious often fatal disease caused by Variola virus of the family Poxviridae. It was completely eradicated in the 1970s. Those who survived were left with pockmarks.

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