Cryptic crossword clue
Live plagued by cancer, ultimately experiencing pain that’s crossing the threshold 9

The most common and most likely answer to this crossword clue is the 9 letter word BREACHING

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Buddy explains!

The straight part
We know that "crossing the threshold" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case crossing the threshold = breaching.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BREACHING mean?

BREACHING verb
  1. To make a breach in.
  2. To violate or break.
  3. (of the sea) To break into a ship or into a coastal defence.
  4. (of a whale) To leap out of the water.
BREACHING noun
  1. The act by which something is breached.

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