Cryptic crossword clue
Lizard has to leave area around rock face 10

The most common and most likely answer to this crossword clue is the 10 letter word CHUCKWALLA

I've seen this crossword clue in Financial Times
C
H
U
C
K
W
A
L
L
A


Buddy explains!

The straight part
We know that "Lizard" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lizard = chuckwalla.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CHUCKWALLA mean?

CHUCKWALLA noun
  1. An iguana, of the genus Sauromalus, living in arid regions of the southwestern United States and northern Mexico.

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