Cryptic crossword clue
Loneliness being isolated on ground 10

The most common and most likely answer to this crossword clue is the 10 letter word DESOLATION

I've seen this crossword clue in The Daily Telegraph
D
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S
O
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Buddy explains!

The straight part
We know that "Loneliness" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loneliness = desolation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DESOLATION mean?

DESOLATION noun
  1. The act of desolating or laying waste; destruction of inhabitants; depopulation.
  2. The state of being desolated or laid waste
  3. A place or country wasted and forsaken.

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