Cryptic crossword clue
Lonely end to the working week, going on for ever 10

The most common and most likely answer to this crossword clue is the 10 letter word FRIENDLESS

I've seen this crossword clue in The Times
F
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Buddy explains!

The straight part
We know that "Lonely" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lonely = friendless.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FRIENDLESS mean?

FRIENDLESS adjective
  1. Without friends (without a friend).

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