Cryptic crossword clue
Look after home when she is out working 5-3

The most common and most likely answer to this crossword clue is the 9 letter word HOUSE-SIT

I've seen this crossword clue in Financial Times
H
O
U
S
E
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S
I
T

Buddy explains!

The straight part
We know that "Look after home" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case look after home = house-sit.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HOUSE-SIT mean?

HOUSE-SIT verb
  1. To live temporarily in someone else's home for the purpose of protecting and tending to it in the owner's or tenant's absence.

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