Cryptic crossword clue
Look down on river holding drinks up 7

The most common and most likely answer to this crossword clue is the 7 letter word DESPISE

I've seen this crossword clue in The Guardian
D
E
S
P
I
S
E

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DESPISE mean?

DESPISE verb
  1. To regard with contempt or scorn.
  2. To disregard or ignore.

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