The most common and most likely answer to this crossword clue is the 6 letter word LOTION
I've seen this crossword clue in Financial Times
L
O
T
I
O
N
More clues leading to the result LOTION
- Left lid off 18, showing balm
- Plenty to do? One involved no longer washing
- Bird scoffing odd bits of this cream
- Parliamentary proposal: “Leader to be replaced by Left” – a cosmetic thing
- Skin care product? Spot’s about gone!
- Great deal no one rejected for cosmetic product
- Look to Spanish uncle to finish carton of cream
- It’s a great deal to charge for skin treatment
- One charged after good deal for beauty treatment
- Skin preparation? Simpleton absorbs it the wrong way
Buddy explains!

The straight part
We know that "cream" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cream = lotion.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LOTION mean?
LOTION noun- A low- to medium-viscosity topical preparation intended for application to unbroken skin.
- A washing, especially of the skin for the purpose of beautification.
- To cover or treat with a lotion.