Cryptic crossword clue
Loose favourite — French one comes first 6

The most common and most likely answer to this crossword clue is the 6 letter word UNPICK

I've seen this crossword clue in The Daily Telegraph
U
N
P
I
C
K

Buddy explains!

The straight part
We know that "Loose" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loose = unpick.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNPICK mean?

UNPICK verb
  1. To undo sewing stitches.
  2. To undo knitting in order to reuse the wool.
  3. To unravel or untangle the threads of a rope etc.
  4. To disassemble.

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